In an important moment for science and data transparency, The Lancet (@thelancet) announced that its 96,000 observational study on hydroxychloroquine has been RETRACTED. On June 4, 2020, three of the authors (Mandeep R. Mehra, MD, MSc, Frank Ruschitzka, MD, Amit N. Patel, MD) of the paper “Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis” have retracted their study.
Retraction from the authors is published here: https://hubs.ly/H0r7gh50
Below is a statement from The Lancet:
They were unable to complete an independent audit of the data underpinning their analysis. As a result, they have concluded that they “can no longer vouch for the veracity of the primary data sources.” The Lancet takes issues of scientific integrity extremely seriously, and there are many outstanding questions about Surgisphere and the data that were allegedly included in this study. The retraction notice is published today, June 4, 2020. The article will be updated to reflect this retraction shortly.
ScienceDaily posted the News Release that was originally published by The Lancet, which is excerpted below:
A large observational study suggests that treatment with the antimalarial drug chloroquine or its analogue hydroxychloroquine (taken with or without the antibiotics azithromycin or clarithromycin) offers no benefit for patients with COVID-19. The study analysed data from nearly 15,000 patients with COVID-19 receiving a combination of any of the four drug regimens and 81,000 controls.
Treatment with these medications among patients with COVID-19, either alone or in combination with macrolide antibiotics, was linked to an increased risk of serious heart rhythm complications in these patients.
Researchers suggest these treatment regimens should not be used to treat COVID-19 outside of clinical trials until results from randomised clinical trials are available to confirm the safety and efficacy of these medications for COVID-19 patients.