Lyrica and Cymbalta are drugs commonly prescribed to treat pain associated with several health issues such as fibromyalgia and diabetic peripheral neuropathy. If your doctor prescribes either one of these medications, please make sure that you are fully aware of their potential side effects. Do not take either of these medicines without first evaluating their risks versus their benefits.


Pregabalin — the generic name for Lyrica — addresses pain caused by neuropathic (nerve) damage due to diabetes, shingles, infection, or spinal cord injury. It can also be combined with other medications to treat focal epileptic seizures.

As noted on the RxList website, Lyrica can trigger an assortment of side effects, including:

• Dizziness
• Drowsiness
• Loss of balance or coordination
• Dry mouth
• Constipation
• Edema
• Breast swelling
• Tremors
• Blurred vision
• Weight gain
• Problems with memory or concentration

The recommended dose of Lyrica is 75-600 mg per day. Alcohol and drugs that cause sedation may increase Lyrica’s sedative effects. There are no adequate studies of Lyrica when administered to pregnant women.


Last updated on on Feb 18, 2019, Cymbalta (generic name: duloxetine) is an anti-depressant drug classified as an selective serotonin and norepinephrine reuptake inhibitor (SNRI) that is used to treat depression, anxiety disorder, and pain caused by diabetic peripheral neuropathy or fibromyalgia. Common side effects of Cymbalta include:

• Nausea
• Constipation
• Diarrhea
• Dizziness
• Drowsiness
• Fatigue
• Insomnia

Per, other Cymbalta side effects include: agitation, erectile dysfunction, nervousness, psychomotor agitation, tension, vomiting, abdominal pain, anorexia, and decreased appetite.

When using Cymbalta to treat depression, the recommended dose is 20 or 30 mg twice daily, or 60 mg a day. Cymbalta may interact with other pain relievers and medications such as aspirin, ibuprofen, and naproxen. Some patients who stop taking Cymbalta may experience anxiety, nausea, nervousness, or insomnia.

Action Steps

If you have taken either Lyrica or Cymbalta, what has been your experience? Has it been favorable? Were there periods where the pain became manageable but you were forced to endure a variety of side effects, such as blurry vision and sensitivity to light, loss of balance, or stomach cramps? Did your doctor disclose any clinical studies about these drugs or advise you about withdrawing from their use? If you had to do it all over again, would you take these same medications again?

Lyrica and Cymbalta: Are these remedies worse than the disease?
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One thought on “Lyrica and Cymbalta: Are these remedies worse than the disease?

  • 2019-10-23 at 9:47 pm

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    Scientists have been able to implant false memories into the brain of a mouse using optogenetics. This could have far-reaching consequences for the 350 million people worldwide that suffer from depression, as Susumu Tonegawa, Professor of Biology and Neuroscience at Massachusetts Institute of Technology explained in a talk at Davos 2016.


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